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A smart home is a component of the Internet of Things (IoT) technology implementations that help people with their daily activities. To link devices to the Internet of Things, a variety of communication methods can be used. Impairments restrict the activities that disabled people can participate in. This paper proposes an automation system that enables disabled people to control televisions (TVs), lights, and fans, any other electrical devices at home, using just voice commands without moving. The Google Assistant feature for mobile phones is used to achieve voice recognition on electronic components. This system also contains the concept of human temperature measurement where the temperature sensor, fixed to the door, checks the temperature of the person and opens when it is normal. This prevents the user from getting infected by the illness, keeping in mind the present situation of covid19. © 2023 IEEE.
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Introduction: Virtual communication has become common practice during the COVID-19 pandemic due to visitation restriction. We aimed to evaluate overall family satisfaction in intensive care unit (FS-ICU) with virtual communication strategies during the COVID-19 pandemic period. Method(s): In this prospective multi-centre study involving three metropolitan hospitals in Melbourne, Australia, the next of kin (NOK) of all the eligible ICU patients between 07/01/2022 and 10/31/2020 were required to complete an adopted version of FS-ICU 24-Questionnaire. Group comparisons were analysed for family satisfaction scores: ICU/ care (satisfaction with care), FS-ICU/dm (satisfaction with information/ decision-making) and FS-ICU total (overall satisfaction with the ICU) were calculated. The essential predictors that influence family satisfaction were identified using quantitative and qualitative analyses. Result(s): Seventy-three out of the 227 patients' NOK who initially agreed, completed the FS-ICU questionnaire (response rate 32.2%). The mean (SD) FS-ICU/total was 63.9 (30.8). The mean score for satisfaction with FS-ICU/dm was lower than the FS-ICU/care (62.1 [30.30 vs. 65.4 [31.4];p 0.001) (Fig. 1). There was no difference in mean FS-ICU/ total scores between survivors (n = 65;89%) and non-survivors (n = 8, 11%). Higher patient APACHE-III score, female NOK and the patient dying in ICU were independent predictors for FS-ICU/total score while a telephone call at least once a day by an ICU doctor was related to higher family satisfaction for FS-ICU/dm. Conclusion(s): There was low overall family satisfaction with ICU care and virtual communication strategies adopted during the COVID-19 pandemic. Effort should be targeted for improving factors with virtual communication that cause low family satisfaction during the COVID-19 pandemic.
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Background: The COVID-19 pandemic, caused by the human coronavirus, SARS-CoV-2, has led to the death of millions across the globe. The SARS-CoV-2 virus is highly infectious, and mutates rapidly. This creates additional challenges for the development of robust therapeutic solutions. Along with modern healthcare, there is a need to explore natural, plant-based antiviral compounds that can be used in the treatment of COVID-19. Objective: The present feasibility study investigates the efficacy of a 13-ingredient Ayurvedic polyherbal formulation, NOQ19, in the management of COVID-19. Methodology: A single-arm, open-label study design was adopted for this feasibility study. 161 RT-PCR-positive COVID-19 patients were enrolled. The enrolled participants were provided with the Ayurvedic intervention - two tablets of NOQ19 thrice daily along with the standard of care treatment. Follow-up COVID-19 RT-PCR tests were conducted on days 5, 10, and 14 or until the patient tested negative. The time taken to turn RT-PCR negative or become asymptomatic was noted. Setting: The study was conducted at Sri Sri Institute for Advanced Research from April 2021 to June 2021. Participants: A total of 161 COVID-19 patients isolating at home were assessed. Intervention: The NOQ19 preparation is a combination of 13 Ayurvedic herbs. Outcomes Measured: RT-PCR tests, the turnaround time to becoming asymptomatic, and regular symptoms assessment. Results: The analysis demonstrated that 74% of the patients tested negative on the RT-PCR within five days of taking NOQ19. Additionally, 98% of the subjects tested negative on the RT-PCR on day 10 after taking NOQ19 and standard of care treatment (as necessary). None of the participants reported any adverse events or side-effects due to NOQ19 medication. Conclusion: The NOQ19 Ayurvedic polyherbal formulation can be an effective and safe option for the symptomatic management of COVID-19.
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Purpose: Intraoral defects in the maxilla cause communication with the nasopharyngeal complex. The surgically removed palate can have a devastating effect on the appearance and speech of the patient. Obturators allow patients to eat and drink without any suspicion of food entering the oroantral cavities/ pharynx during mastication. This clinical report describes fabrication of a closed hollow bulb obturator using the two-piece double flask technique. Method(s): After the final teeth arrangement was completed, teeth over the defect were removed and separately processed using heat cure acrylic resin. Both the segments are combined by autopolymerizing acrylic resin to form a single hollow-bodied obturator. Conclusion(s): This technique uses a double flasking method of the two segments to control the thickness of the bulb in the defect area, thus decreasing the weight of the obturator.Copyright © 2020 Ubiquity Press. All rights reserved.
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Background: COVID-19 pandemic situation made the pharmaceutical companies develop the vaccine with different formulations in a short period. Objectives: The main objective of the review is to focus on different types of vaccine formulations available globally and the importance of technology transfer in vaccine development associated with potential risks. Results: Research on vaccine development led to various types of vaccines, such as Inactivated vaccines, Live Attenuated vaccines, Ribonucleic acid (RNA) and Deoxyribonucleic acid (DNA) vaccines, viral vector vaccines, and Protein Subunit Vaccines for COVID-19. But the process of vaccine development and technology transfer is lined with various risks and challenges. Through risk assessment, we found some major potential risks involved in product development; this leads to a smoother and more efficient method to develop safe vaccines available for public health. Conclusions: This review will explain the significance of technology collaboration for the faster development of various formulations of vaccines globally
Antecedentes: La situación de pandemia de COVID-19 hizo que las empresas farmacéuticas desarrollaran la vacuna con diferentes formulaciones en un corto período. Objetivos: El objetivo principal de la revisión es centrarse en los diferentes tipos de formulaciones de vacunas disponibles a nivel mundial y la importancia de la transferencia de tecnología en el desarrollo de vacunas asociado con los riesgos potenciales. Resultados: La investigación sobre el desarrollo de vacunas condujo al desarrollo de varios tipos de vacunas, como vacunas inactivadas, vacunas vivas atenuadas, vacunas de ácido ribonucleico (ARN) y ácido desoxirribonucleico (ADN), vacunas de vectores virales y vacunas de subunidades de proteínas para COVID-19. Pero el proceso de desarrollo de vacunas y transferencia de tecnología está lleno de varios riesgos y desafíos. A través de la evaluación de riesgos, encontramos algunos riesgos potenciales importantes involucrados en el desarrollo de productos, lo que conduce a un método más fluido y eficiente para desarrollar vacunas seguras disponibles para la salud pública. Conclusiones: Esta revisión dará una idea de la importancia de la colaboración tecnológica para el desarrollo más rápido de varias formulaciones de vacunas a nivel mundial
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Humans , Technology Transfer , COVID-19 Vaccines , Vaccine Development , Risk AssessmentABSTRACT
The new corona virus illness (COVID-19) swept around the world, quickly creating a serious international disaster. For the treatment and prevention of COVID-19, apitherapy appears to be a viable source of pharmacological and nutraceutical medicines. Honey, pollen, propolis, royal jelly, beeswax, and bee venom, for example, have been demonstrated to have significant antiviral action against infections that cause severe respiratory syndromes, including those produced by human corona viruses. Furthermore, many of these natural products are involved in the induction of antibody production, maturation of immune cells, and stimulation of innate and adaptive immunological responses and many of them are involved in the induction of antibody production, maturation of immune cells, and stimulation of innate and adaptive immunological responses.
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The advent of the COVID-19 pandemic in the final months of 2019 prompted an extraordinary response on the part of the scientific community, with fundamental research on the biology of the virus and the human immune response, and development of testing, therapeutics, and vaccines occurring on an unprecedentedly short timescale. Within a year after the worldwide outbreak of the disease, more than 40 vaccine candidates had emerged, with 21 candidates in phase 3 trials or already being used on an emergency basis. Many of these vaccines have involved innovative platforms. In this concise review, the authors will summarize the characteristics and performance of the leading vaccines and discuss considerations of virus mutations and asymptomatic spread that may affect the ability of the worldwide community to use these vaccines as a means to defeat the pandemic and restore pre-COVID-19 normality.
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Background: In the last two years, COVID-19 pandemic caused by SARS-CoV-2 has created a mass destruction among humanity causing a major health crisis around the world. With the emergence of new strains of the virus, lack of targeted drugs and antimicrobial resistance, there is a dire need to discover specific antiviral with minimum side effects targeted against COVID-19. Objective: The present study evaluates the antiviral efficacy of a novel Ayurvedic polyherbal formulation, NOQ19, composed of a 13 well known herbs, in a cell-based setting. Methodology: Vero E6 (CL1008), the African green monkey kidney epithelial cell, were infected with SARS-CoV-2 virus (isolate USA-WA1/2020) in a 96 well-plate. NOQ19 test material was diluted at different concentration: 0.05 mg/ml, 0.1 mg/ml, 0.2 mg/ml, 0.3 mg/ml, 0.4 mg/ml, 0.5 mg/ml, 0.6 mg/ml, 0.7 mg/ml, 0.8 mg/ml and 0.9 mg/ml. These different concentrations of NOQ19 were added to infected cells respectively and incubated for 3 days in 5% CO2 incubator. Remdesivir was used as a positive control. The cells were finally fixed with formaldehyde, stained with crystal violet and plaques were visualized. The number of plaques were counted to determine the PFU(plaque forming units)/ml. Results: The results of the present study demonstrated an excellent an antiviral efficacy of NOQ19 at 0.9 mg/ml concentration, eliminating 100% virus. The IC50 of the drug was found to be 0.2 mg/ml. Conclusion: There is limited data around pre-clinical efficacy of polyherbal Ayurvedic drugs. Ayurvedic and herbal formations need to be tested in a preclinical setting to support the human data. The results of the present study demonstrated viral load reduction using NOQ19 in Vero E6 cell lines infected with SARS-CoV-2 virus. These result along with other preclinical and clinical trials could further evaluate the efficacy of NOQ19 as a potential therapeutic option in the fighting the COVID-19 challenge.
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Background: Alcohol-based hand sanitizer (ABHS) usage has become one of the COVID-19 pandemic-related adapted responses. Some disulfiram-ethanol reactions are reported in people who use alcohol-based hand rub/sanitizer and take Disulfiram as a treatment for their alcohol use disorders. Aim & Objective: To determine the practice experiences of psychiatrists on disulfiram prescription to alcohol use disorder victims. Methodology: A cross-sectional study on the psychiatrists to find the experiences of disulfiram prescription to their clients with alcohol use disorders during the COVID-19 pandemic. Results: Nearly 84 (51%) were reverted with a completed questionnaire. Among the respondents, 28 (33.3%) of the respondents decreased to prescribe Disulfiram, 48 (57.1%) reported that their patients stopped using ABHS due to fear of Disulfiram-Ethanol Reaction (DER), and 20 (23.8%) responders notified that their patients were expressed their worry on DER with Disulfiram and ABHS. Conclusion: Disulfiram prescribed for alcohol use disorders;treatment got peculiar experiences with the incidences of DER reported with Alcohol-based hand sanitizer. Many practitioners were scared to prescribe disulfiram due to DER with ABHS. The prevailing evidence that there is no possibility of cutaneous application of ABHS producing enough significant DER. Hence using ABHS is not a contraindication for disulfiram prescription. © 2022, Indian Association of Preventive and Social Medicine. All rights reserved.
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As education field has become online due to covid in both schools and colleges, e-learning security has become an important issue. An e-Learning framework provides a collection of online services that are helpful for the learners, resource persons and others who are involved in enhancing the management and delivery of education to all sections of people. The two most important aspects of an e-Learning system are better search of learning resources and the secure authentication between the learner and the trainer. This chapter introduces two novel methods: (i) optimization of Learning Object (LO) search based on learners' characteristics, (ii) secure authentication of trainers and learners using visual cryptography. Storage and delivery of optimal resources that are well suited for individual learner is always a challenging task. To find the best learning objects, an enhanced attribute-based Ant Colony Optimization (ACO) algorithm that provides flexibility for the learners based on learner characteristics is proposed. A novel visual cryptography-based technique with kite-based partition technique is designed to perform file sharing and blockchain-based secure authentication and verification of valid learners is proposed for the framework. Several measures like match ratio, relevancy factor, and heuristic values show the efficiency of the proposed ACO search technique in the context of an e-Learning framework. © 2022 by World Scientific Publishing Co. Pte. Ltd.
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Infodemic' (an overabundance of information) that makes it tough for people to find responsible sources and reliable guidance when they need it. This generates a need to know whether the public are able to distinguish fake news from true ones and the information sources used. The study aims to determine the impact of infodemic on public perception of health during the COVID-19 pandemic and to assess its impact on the psychological well-being of the public. An online web based cross sectional study was conducted among people who were aged above 15 years. The data was collected through online mode by providing google links to fill the validated questionnaire form through various social media platforms. The questionnaire consists of demographic details, knowledge and practice related questions. The data was analyzed using Chi-square test. A total of 715 responses were considered for analysis in which the majority of the age group belongs to 18 - 24 years and mostly living in urban (44%) and rural (41%). Information Sources mostly used include Internet (630), Mobile phone usage (630), and TV (530). Standard (or) Trusted sources according to people were Government websites (407). It was observed that most people have good knowledge about COVID-19 prevention and were practicing the safety measures. The study concludes that availability of abundance of information sources and lack of awareness on how to cross-check made people to follow some activities in the view of protection without knowing the truth. This impact of infodemic can be controlled by health care professionals including pharmacists by giving updated and evidence-based scientific advice on reliable COVID-19 information to their communities via flyers and multimedia.
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The new eruption of COVID-19 has overpowered the world, convinced lockdowns and pushed general clinical consideration systems. Covid is known to be a significantly overpowering disease, and spoiled individuals at first don't show signs, while some stay asymptomatic. The new eruption of COVID-19 has overpowered the world, convinced lockdowns and focused on general clinical consideration structures. Covid is known to be significantly compelling contamination, and corrupted individuals at first don't show signs, while some stay asymptomatic. In like manner, various assemblies have shown uncommon interest in cell contact following applications that help with robotizing the inconvenient task of following all new contacts of late perceived polluted individuals. We give an overview of several suggested methods following results in the increase, many of which have been distributed nationally, and discuss the concerns clients have expressed about their use. © 2022 IEEE.
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From past two years world is suffering with the COVID-19 pandemic which mainly infecting human lungs. Lung infection can be caused by different viruses and bacteria, diagnosis of Lung infections can be done using Radiography X-ray images. Due to similarity in infections there are high chances that other infections can be falsely considered as COVID-19. Manual chest X-ray diagnosis for COVID-19 requires a radiologist and a time taking process, hence it is not a good choice as the covid-19 can spread in no time from person to person.Hence there is need for automatic process of Covid-19 detection and classification of different chest disease. We worked on developing a deep transfer learning model which will accurately classify various chest infections such as COVID-19, Lung-Opacity, Tuberculosis, Viral Pneumonia, We used transfer learning approach which uses existing deep learning models and adding our layers for classification. This work compares various pre-trained models and also convolutional neural network by considering data set of different infections with total 4526 images belonging to 5 classes for training, 647 images belonging to 5 classes for validation, 746 images for testing. © 2022 IEEE.
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A series of 4-Aminophenyl-1H 1,2,3-traizole based benzofuran analogs were synthesized with high yields straightforwardly via microwave irradiation methods than conventional methods. The structures of synthesized compounds were confirmed based on IR, 1H, 13C NMR, and HR mass spectral analysis. All the synthesized compounds were subjected to evaluation of their in vitro anticancer activity with MCF-7, PC-3, and HeLa cell lines by MTT assay, and compounds 7m, 7j, 7e, 7g, 7b, 7h, and 7c have shown good results compared to standard Doxorubicin. Further, in vitro antimicrobial activity of synthesized compounds examined by Agar Disc Diffusion method by taking gram-positive, gram-negative bacterial, and fungal strains and turned out with encouraging results compared to standard Ciprofloxacin and Fluconazole respectively. Furthermore, molecular docking studies were carried out to find out H-bonding interactions, hydrophobic interaction with docking scores of synthesized compounds. We have carried out molecular docking on COVID-19 study with COVID-19 main protease enzyme and got outstanding binding interactions. © 2022
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Objectives: A scoping review was conducted to examine the breadth of evidence related to telehealth innovations being utilized in the treatment of Opioid Use Disorder (OUD) with buprenorphine and its effect on patient outcomes and healthcare delivery. Background(s): With the opioid epidemic worsening from year to year, there is a critical need to connect with this growing population and get them access to life-saving interventions. Buprenorphine is shown to be associated with lower overdose rates and a decrease in opioid-related acute care, but has historically been underutilized in treatment for OUD. Previous studies have determined that geographical barriers and lack of access to DEA-waivered providers are common obstacles towards starting MAT. Telehealth presents itself as a solution to this discrepancy and is becoming more feasible to integrate into clinical practice. Method(s): The authors systematically searched seven databases and websites for peer-reviewed and gray literature related to telehealth solutions for buprenorphine treatment published between 2008 and March 18, 2021. There were 69 articles which met inclusion criteria. Result(s): According to the reviewed literature, incorporation of telehealth technology with Medication Assisted Treatment (MAT) for OUD is associated with higher patient satisfaction, comparable rates of retention, and an overall reduction in health care costs. Conclusion(s): Utilization of synchronous videoconferencing has reportedly been effective in increasing access to and usage of buprenorphine by overcoming both geographical and logistical barriers. This has been made possible through the expansion of telehealth technologies and a substantial push towards relaxed federal guidelines, both of which were quickly escalated in response to the COVID-19 pandemic. Future research is needed to fully quantify the effect of these factors;however, the results appear promising thus far and should urge policymakers to consider making these temporary policy changes permanent. (Figure Presented) .
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Introduction: The COVID-19 pandemic and lockdown restrictions have significantly affected delivery of healthcare amongst UK hospitals. Some centres had reduced screening rates of pre mature babies, while others documented higher rates. The purpose of this study is to explore the effect of first UK lockdown restrictions on ROP prevalence and treatment. Method(s): Participants were pre-mature babies born during UK first Lockdown between 23 March 2020 to 20th October 2020 at Royal London Hospital. They were identified using the national neonatal database (BadgerNet). Severity of ROP, birthweight, gestational age, treatment and total number were compared to same data in corresponding dates in 2019. Independent T test was used to compare the demographics and a chi-squared test was used to compare the prevalence of various stages of ROP between the two groups. Result(s): 107 babies were included,(2020 n = 51, 2019 n = 56). Although the mean birth wight in 2020 (991 g) was less than that in 2019 (1021grams), this was not significant (P = 0.6). More babies were born below 1000 g in 2020 (60%) compared to 2019 (53%) (P = 0.1). The mean gestational age (27 weeks) was equal in the two years (P = 0.7). 62.7% of babies in 2020 had grade 2 or more of ROP compared to 50% in 2019. Treatment rate was 14% in 2020 compared to 5 % in 2019 (P = 0.1). Conclusion/Relevance: Our pilot study showed no statistical significance in the prevalence of babies with ROP between 2019 and 2020, However we have subjectively noted younger and smaller babies during the lockdown, hence the higher treatment rate. Copyright © 2022
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SESSION TITLE: Post-COVID-19 Infection Complications SESSION TYPE: Case Report Posters PRESENTED ON: 10/17/2022 12:15 pm - 01:15 pm INTRODUCTION: COVID-19 is a systemic infectious and inflammatory disease, with multifactorial immunosuppression during the recovery phase which predisposes to serious infections. Although the gastrointestinal (GI) system is often affected in post-acute COVID-19 patients, liver abscess formation is rare. Here, we present a case of septic shock caused by a bacterial liver abscess in a survivor of severe COVID-19. CASE PRESENTATION: 78-year-old man with no past medical or surgical history was admitted to an outside hospital (OSH) with severe COVID-19 pneumonia and discharged after 14 days. He required high flow nasal cannula and was treated with Remdesevir, Dexamethasone, and Baricitinib. D-dimer was elevated without evidence of acute venous thromboembolism. Four weeks later he returned to the OSH due to dyspnea and was found to be hypotensive and hypoxemic. Laboratories showed leukocytosis, hyperlactatemia, and mild elevation of total bilirubin and transaminases. Whole-body CT scan revealed a small RUL pulmonary embolus and a 7cm multifocal loculated complex fluid collection indicative of a left hepatic lobe abscess. He was managed with supplemental oxygen, anticoagulation, broad-spectrum antibiotics, IV fluids, and vasopressors and transferred to our hospital for abscess drainage. The liver abscess was aspirated after an abdominal MR confirmed the findings and the septic shock subsequently resolved. Body fluid and blood cultures grew pan-sensitive Klebsiella pneumoniae. Antibiotics were narrowed to levofloxacin. He remained hemodynamically stable and was discharged home. DISCUSSION: In our patient, the underlying cause of bacterial inoculation of the liver and abscess formation remains unclear and is not fully explained by drug-induced immunosuppression given the frequency with which these medications are used. Hepatic abscesses often develop after liver injury and, in COVID-19, multiple mechanisms of liver injury have been proposed which may predispose to abscess formation. Specifically, in our case, it is likely that hypoxic hepatitis and arterial/venous thrombosis from hypercoagulability played a role in abscess formation given the need for supplemental oxygen and the presence of a pulmonary embolism. Additionally, in COVID-19, increased hepatobiliary expression of ACE2 may contribute to direct viral cytotoxicity of the liver and substantial dysbiosis may lead to cholestasis and bacterial translocation. CONCLUSIONS: Our case is unique and underlines the importance of having a high index of suspicion and monitoring for "occult infections,” such as liver abscesses in the COVID-19 recovery phase, even in those without prior GI medical history and with non-specific signs and symptoms. Further elucidation of the cause of liver injury and abscess formation are warranted;however, early identification and treatment can reduce morbidity and mortality. Reference #1: Nalbandian, A., et al, 2021. Post-acute COVID-19 syndrome. Nat Med, 27(4): 601–615. Reference #2: Liemarto, A.K., et al, 2021. Liver abscess with necrosis in post COVID-19: A case report. Ann Med Surg (Lond), 72: 103107. Reference #3: Alhaddad O., et al, 2022. A case report of COVID-19 evoked cholangitic liver abscess. Egypt Liver J, 12(1):5. DISCLOSURES: No relevant relationships by Christian Ascoli No relevant relationships by Anna Duchnowska No relevant relationships by Tirsa Ferrer Marrero No relevant relationships by Manasa Reddy
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In the past, the church was a place of comfort and healing. However, COVID-19 brought about a profound change that saw life as we knew it come to an abrupt halt. Services that were not considered essential, including that of the church, were forced to close their doors. Religious bodies and critical leaders of society did not recognise churches as an integral, life-giving part of the community and world at large. Secular organisations offering essential services could be operated under strict conditions. However, the church remained closed. Despite lockdown restrictions being eased, churches still ensued an uphill battle to open their doors. Strict limits were imposed when the church was eventually allowed to resume fellowship. This was imposed by the government to prevent the spread of COVID-19. Pastors had to look to other mediums to propagate the gospel to ensure the church’s survival. Social media have become the most common medium used by the church during COVID-19 to propagate the gospel. This paper aims to describe the forms of communication used by the cell church post-COVID-19 to ensure its survival. The early church gathered in homes as there were no designated buildings where they could worship. COVID-19 forced Christians to have fellowship in their homes and connect with their pastors via social media. The cell church is built around the Jethro Model. It was a form of leadership suggested to Moses by his father-in-law when he noticed how he handled the issues of the Hebrew people. The cell group provides spiritual nourishment for each other and encourages fellowship between family and friends. With cell groups being closed as a result of the restrictions imposed during the COVID-19 pandemic, this has hindered the spiritual growth of believers. This paper proposes that cell churches use all forms of communication until cell groups become functional again. Secondary sources are used as part of the research methodology for this study. © 2022 Open Access/Author/s - Online @ http//: www.pharosjot.com